Runes and powers
Farm the least-collected lesser Runes
Dungeon Anomaly rewards favor lesser Rune types you have collected least, making this a targeted collection-completion loop.
Dungeon Anomaly completion reward after the final boss.
Repeatable while collection gaps remain. Lesser Rune rewards are still variable, even with the collection weighting.
Stop when the lesser Rune types you wanted are collected, or switch to Elite Dungeon Anomalies if your goal is a Runestone for power extraction.
Open a guide to find other locations and see what the item is used for.
Dungeon Anomaly rewards favor lesser Rune types you have collected least, making this a targeted collection-completion loop.