Endgame and character progression
Unlock and tune Mayhem Mode
Set the post-campaign challenge level used by endgame runs and Eridium farming.
WHERE & HOW TO FARM
Unlock and tune Mayhem Mode
Sanctuary III after the main campaign, using the in-game Mayhem access point.
Before you go
- Complete the main story.
- Return to Sanctuary III after the campaign.
- Have a repeatable activity available for judging whether a selected level is manageable.
Farming steps
- Finish the campaign and return to Sanctuary III.
- Interact with the Mayhem access point to open the mode settings.
- Select a modest Mayhem level to begin testing your build.
- Travel to a familiar named enemy or Circle of Slaughter and attempt a clear.
- Check whether enemies remain manageable and whether you can complete the route reliably.
- Raise the level when clears are comfortable; lower it when fights become inconsistent or overly slow.
- Mayhem increases Eridium rewards according to the cited route, but difficulty only helps if you can still complete the activity.
- Reassess after major gear or build changes instead of treating one level as permanent.
Repeat, collect and use
Mayhem settings can be adjusted as needed; this is a tuning process rather than a limited reward. Activity rewards remain tied to the content you choose to run.
Common mistakes
- Looking for Mayhem before finishing the story: complete the campaign first.
- Raising the setting based only on damage numbers: test actual completion speed and survivability.
- Staying at a level that makes every farm unreliable: lower it until your build clears consistently.
When to stop or switch
Stop adjusting when you find a level that supports reliable clears and useful rewards; revisit the setting after your build changes.
Sources & fact checks
What you can get here
Open a guide to find other locations and see what the item is used for.