Soul Essence and permanent growth
Collect Soul Essence from each run
Build permanent Talent progress from regular Adventure play.
Adventure rooms and boss encounters across the four acts.
Repeat Adventure runs as long as you want; Essence collection and permanent Talent spending continue across runs.
Pause farming when you have enough banked Essence for the Talent you targeted, or switch to a lower difficulty if repeated failed runs slow your progress.
Open a guide to find other locations and see what the item is used for.
Build permanent Talent progress from regular Adventure play.