Chamber bosses and challenges
Solve Chaos Chamber runes for secret bosses
Optional rune puzzles can open a red portal to secret encounters after the normal final boss.
WHERE & HOW TO FARM
Solve Chaos Chamber runes for secret bosses
Chaos Chamber encounter rooms, on walls after clearing an encounter; successful runes lead to a red portal after the normal final boss.
Before you go
- Finish the campaign and unlock the Chaos Chamber.
- Bring a build capable of handling optional boss fights.
- Be willing to skip a puzzle if the main run is already at risk.
Farming steps
- After clearing an encounter, scan nearby walls for an interactable yellow, blue or green rune.
- Activate a rune only when ready to attempt its puzzle.
- For yellow, destroy the spawned orb while staying clear of its moving light.
- For blue, guide the orb to its destination without hitting obstacles, then shoot it there.
- For green, shoot the spores marked with a purple glow as the challenge unfolds.
- Continue the regular run and defeat its final boss.
- If the rune challenges were successful, use the opened red portal to enter the optional secret encounter.
- Keep the yellow light and blue route in view before firing or moving; failed attempts are limited.
- Prioritize finishing the ordinary run if a puzzle is consuming attempts or your build is low on resources.
Repeat, collect and use
Rune appearances are part of repeatable Chamber runs, but each puzzle attempt has limited chances within that run.
Common mistakes
- Treating every rune as mandatory: the secret route is optional, so skip it when needed.
- Shooting the blue orb before it reaches its destination: guide it safely first.
- Standing in the yellow light: avoid the beam while damaging the orb.
When to stop or switch
Skip further puzzles when their attempts are exhausted or the added encounter threatens completion of the main run.
What you can get here
Open a guide to find other locations and see what the item is used for.