Cells and unlocks
Unlock the Daily Challenge with the Challenger Rune
Complete a one-time progression unlock that opens access to the Daily Challenge and its separate blueprint milestones.
Defeat the Concierge at the Black Bridge, then use the Daily Challenge entrance in Prisoners’ Quarters.
The Challenger Rune unlock is one-time. Daily Challenges can be completed on later days, but that does not make their blueprint milestones an endless repeat reward.
Stop pursuing this unlock once the Challenger Rune is obtained and the Daily Challenge entrance is available; use normal runs for repeatable cells.
Open a guide to find other locations and see what the item is used for.
Complete a one-time progression unlock that opens access to the Daily Challenge and its separate blueprint milestones.