Boss Stem Cells open routes and raise the stakes
Activate the required number of Boss Stem Cells for a run to access gated doors and routes; higher difficulty also increases enemy challenge and cell drops.
Dead Cells FARMING GUIDESKnow what to farm.
Know what to farm.
And where to go.
Dead Cells remains a complete released roguelite; its creators ended new creative content with Update 35. Persistent cells unlock gear at the Collector, while Boss Stem Cells raise difficulty and open new branches. Use Hunter’s Grenade to force a missing enemy blueprint, or Boss Rush for a contained boss-and-cell run.
16 farming guides · PC / Global, base game and installed DLC routes labeled
What matters before you farm
Unlock requirements, costs and tips to help you get started.
Force a blueprint from an eligible enemy
Hunter’s Grenade turns an eligible enemy into an Elite. Weaken it until the Blueprint Extractor can be used, then finish the extraction before defeating it.
Sources & fact checks
Spend Boss Rush cells before leaving
Boss Rush cells belong to that run. Invest them at the Legendary Forge or Collector before exiting, or they will not carry into a normal run.
Sources & fact checks
Farm with a purpose
Prioritizes useful cell and blueprint goals, then the BSC gates that open progression routes, followed by repeatable cell and Boss Rush farms.
Cells and unlocks
Collector cell unlocks from Prisoner’s Quarters
Turn cells earned during runs into permanent gear and account progression.
Boss Cell progression
Unlock the second Boss Stem Cell
Advance difficulty progression to reach routes and rewards gated behind two active cells.
Cells and unlocks
Cell vats behind BSC doors
Use difficulty-gated rooms to find extra cells and useful route rewards.
Boss Cell progression
Open Ancient Sewers with one BSC
Access the Ancient Sewers branch and its distinct encounters on a one-cell run.
Boss Cell progression
Unlock Cavern route with two BSC
Open a two-cell route to the Cavern and access its higher-difficulty content.
Blueprint hunting
BSC-gated boss blueprints
Complete boss-linked unlocks while progressing through the required difficulty sequence.
Cells and unlocks
Browse more guides in this category.
Cells and unlocks
Collector cell unlocks from Prisoner’s Quarters
Turn cells earned during runs into permanent gear and account progression.
Cells and unlocks
Cell vats behind BSC doors
Use difficulty-gated rooms to find extra cells and useful route rewards.
Cells and unlocks
Unlock the Daily Challenge with the Challenger Rune
Complete a one-time progression unlock that opens access to the Daily Challenge and its separate blueprint milestones.
Cells and unlocks
Boss Rush cell and forge run
Collect mode-contained cells and convert them into permanent progression before leaving.
Cells and unlocks
Invest cells in the Legendary Forge after a boss
Turn ordinary-run cells into persistent improvements to future gear quality.
Cells and unlocks
Collect transition-door cells during a timed biome route
Adds a repeatable transition-room cell source with an explicit pacing goal, separate from Boss Stem Cell-gated vaults.
Blueprint hunting
Browse more guides in this category.
Blueprint hunting
BSC-gated boss blueprints
Complete boss-linked unlocks while progressing through the required difficulty sequence.
Blueprint hunting
Hunter’s Grenade target blueprint
Turn an eligible enemy into a deliberate blueprint target instead of waiting for a random drop.
Blueprint hunting
Daily Run secret blueprints
Earn fixed milestone blueprints from Daily Challenge completions and add them to the Collector’s list.
Blueprint hunting
Unlock Wish from Boss Rush Trial 3
Targets the Wish blueprint through its listed Boss Rush Trial 3 reward.
Boss Rush rewards
Browse more guides in this category.
Boss Rush rewards
Legendary Forge investment
Permanently improve the chance that future gear drops have higher quality.
Boss Rush rewards
Boss Rush Tier 1 weapon and skill drops
Use a contained boss sequence to practice and earn mode-local cells for upgrades.
Boss Rush rewards
DIY Boss Rush custom boss route
Choose a focused sequence of unlocked bosses for practice and mode-local cell collection.
Boss Cell progression
Browse more guides in this category.
Boss Cell progression
Unlock the second Boss Stem Cell
Advance difficulty progression to reach routes and rewards gated behind two active cells.
Boss Cell progression
Open Ancient Sewers with one BSC
Access the Ancient Sewers branch and its distinct encounters on a one-cell run.
Boss Cell progression
Unlock Cavern route with two BSC
Open a two-cell route to the Cavern and access its higher-difficulty content.
EXPLORE YOUR NEXT SESSION
Browse goals & materials
Recommended farming guides. Search by item, goal or location.
Cells and unlocks
Collector cell unlocks from Prisoner’s Quarters
Turn cells earned during runs into permanent gear and account progression.
Boss Cell progression
Unlock the second Boss Stem Cell
Advance difficulty progression to reach routes and rewards gated behind two active cells.
Cells and unlocks
Cell vats behind BSC doors
Use difficulty-gated rooms to find extra cells and useful route rewards.
Boss Cell progression
Open Ancient Sewers with one BSC
Access the Ancient Sewers branch and its distinct encounters on a one-cell run.
Boss Cell progression
Unlock Cavern route with two BSC
Open a two-cell route to the Cavern and access its higher-difficulty content.
Blueprint hunting
BSC-gated boss blueprints
Complete boss-linked unlocks while progressing through the required difficulty sequence.
Blueprint hunting
Hunter’s Grenade target blueprint
Turn an eligible enemy into a deliberate blueprint target instead of waiting for a random drop.
Blueprint hunting
Daily Run secret blueprints
Earn fixed milestone blueprints from Daily Challenge completions and add them to the Collector’s list.
Cells and unlocks
Unlock the Daily Challenge with the Challenger Rune
Complete a one-time progression unlock that opens access to the Daily Challenge and its separate blueprint milestones.
Blueprint hunting
Unlock Wish from Boss Rush Trial 3
Targets the Wish blueprint through its listed Boss Rush Trial 3 reward.
Cells and unlocks
Boss Rush cell and forge run
Collect mode-contained cells and convert them into permanent progression before leaving.
Boss Rush rewards
Legendary Forge investment
Permanently improve the chance that future gear drops have higher quality.
Cells and unlocks
Invest cells in the Legendary Forge after a boss
Turn ordinary-run cells into persistent improvements to future gear quality.
Cells and unlocks
Collect transition-door cells during a timed biome route
Adds a repeatable transition-room cell source with an explicit pacing goal, separate from Boss Stem Cell-gated vaults.
Boss Rush rewards
Boss Rush Tier 1 weapon and skill drops
Use a contained boss sequence to practice and earn mode-local cells for upgrades.
Boss Rush rewards
DIY Boss Rush custom boss route
Choose a focused sequence of unlocked bosses for practice and mode-local cell collection.
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